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CRBN ligand-348

CAT: 0804-HY-W953469Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W953469Size:1 Each
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Description
CRBN ligand-348 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-348 can be linked to a target protein ligand via a linker to form a PROTAC.
CAS Number
2925095-11-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C1NC(=O)CCN1C2=CC=C(N)C=3C=NNC32
Molecular Formula
C11H11N5O2
Molecular Weight
245.24
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

Chemical Information

1-(4-amino-1H-indazol-7-yl)-1,3-diazinane-2,4-dione
CAS Number2925095-11-8
PubChem CID169548436
IUPAC Name1-(4-amino-1H-indazol-7-yl)-1,3-diazinane-2,4-dione
Molecular FormulaC11H11N5O2
Molecular Weight245.24
XLogP-0.5
Topological Polar Surface Area104
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count18
Formal Charge0
Complexity374
SMILES
C1CN(C(=O)NC1=O)C2=C3C(=C(C=C2)N)C=NN3
InChI
InChI=1S/C11H11N5O2/c12-7-1-2-8(10-6(7)5-13-15-10)16-4-3-9(17)14-11(16)18/h1-2,5H,3-4,12H2,(H,13,15)(H,14,17,18)
InChIKey
BYZGJDXWWLSWKJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(4-amino-1H-indazol-7-yl)-1,3-diazinane-2,4-dione
CAS: 2925095-11-8
CID: 169548436
Formula: C11H11N5O2
MW: 245.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight245.24
XLogP3-0.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass245.09127461
Monoisotopic Mass245.09127461
Topological Polar Surface Area104 Ų
Heavy Atom Count18
Formal Charge0
Complexity374
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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