Totrombopag (choline)

Totrombopag (choline)

• CAS Number: 851606-62-7
• UNSPSC Description: Totrombopag (SB-559448) choline is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag choline initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag choline can be used to study platelet production and megakaryocyte biology[1].
• Target Antigen: Thrombopoietin Receptor
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/totrombopag-choline.html
• Smiles: O=C1N(C2=CC=C(C)C(C)=C2)N=C(C1/N=N/C3=C(O)C(C4=CC(C5=NN=N[N-]5)=CC=C4)=CC=C3)C.OCC[N+](C)(C)C
• Molecular Weight: 569.66
• References & Citations: [1]Alper P B, et al. Discovery and biological evaluation of benzo [a] carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor[J]. Bioorganic & medicinal chemistry letters, 2008, 18(19): 5255-5258.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported