ZZW-115

• Description:

  ZZW-115 is a potent NUPR1 inhibitor, with a Kd of 2.1 μM. ZZW-115 induces tumor cell death by necroptosis and apoptosis. Anticancer activity[1][2].

• UNSPSC:

  12352005

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/zzw-115.html

• Purity:

  99.88

• Solubility:

  10 mM in DMSO

• Smiles:

  FC (C (C=C1N2CCCN3CCN (CCN (C) C) CC3) =CC=C1SC4=C2C=CC=C4) (F) F

• Molecular Formula:

  C24H31F3N4S

• Molecular Weight:

  464.59

• References & Citations:

  [1]Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129 (6) :2500-2513. Published 2019 Mar 28.|[2]Santofimia-Castaño P, et al. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. Cells. 2019;8 (11) :1453. Published 2019 Nov 17.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Citation 01:

  Research Square Preprint. 2024 Feb 20.|BMC Med. 2022 Oct 19;20 (1) :365.|J Cell Mol Med. 2025 Apr;29 (7) :e70519.|Mol Cancer. 2024 May 28;23 (1) :113.

• CAS Number:

  801991-87-7