ULK-101

• UNSPSC Description:

  ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress[1].

• Target Antigen:

  ULK

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ULK-101.html

• Purity:

  99.96

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles:

  FC1=CC=C(C(C=N2)=CN3C2=C(C4=CSC(C(N[C@@H](C5CC5)C(F)(F)F)=O)=C4)C=N3)C=C1

• Molecular Weight:

  460.45

• References & Citations:

  [1]Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2443816-45-1