ULK-101

CAT: 0804-HY-114490-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114490-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress[1].
CAS Number
[2443816-45-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ULK
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ULK-101.html
Purity
99.96
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C(C=N2)=CN3C2=C(C4=CSC(C(N[C@@H](C5CC5)C(F)(F)F)=O)=C4)C=N3)C=C1
Molecular Formula
C22H16F4N4OS
Molecular Weight
460.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ULK1; ULK2

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