ULK-100

• Description :

  ULK-100 is a highly selective and potent ULK1 kinase inhibitor with an IC50 value of 1.6 nM. ULK-100 is promising for research of autophagy-related diseases (e.g., KRAS-mutant lung cancer, glioblastoma) [1].

• UNSPSC :

  12352005

• Target :

  ULK

• Related Pathways :

  Autophagy

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  O=C(C1=CC(C2=C3N=CC(C4=CC=C(OCCN5CCCCC5)C=C4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F

• Molecular Formula :

  C29H32F3N5O2S

• Molecular Weight :

  571.66

• References & Citations :

  [1]Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ULK1

• CAS Number :

  [945377-65-1]