ULK-100

• Description:

  ULK-100 is a highly selective and potent ULK1 kinase inhibitor with an IC50 value of 1.6 nM. ULK-100 is promising for research of autophagy-related diseases (e.g., KRAS-mutant lung cancer, glioblastoma) [1].

• UNSPSC:

  12352005

• Target:

  ULK

• Related Pathways:

  Autophagy

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  O=C(C1=CC(C2=C3N=CC(C4=CC=C(OCCN5CCCCC5)C=C4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F

• Molecular Formula:

  C29H32F3N5O2S

• Molecular Weight:

  571.66

• References & Citations:

  [1]Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ULK1

• CAS Number:

  [945377-65-1]