PROTAC CYP1B1 degrader-2
CAT:
804-HY-158429
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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PROTAC CYP1B1 degrader-2
UNSPSC Description:
PROTAC CYP1B1 degrader-2 (compound PV2) is a von Hippel-Landau (VHL) E3 ligase-based CYP1B1 degrader with the DC50 of 1.0 nM at 24 h in A549/Taxol cells. PROTAC CYP1B1 degrader-2 inhibits growth, migration, and invasion of A549/Taxol cell(Sturcture Note:(Blue: VHL ligand (HY-112078), Black: linker (HY-W007700), Pink: CYP1B1 ligand (HY-159006)[1].Target Antigen:
Cytochrome P450; PROTACsType:
Reference compoundRelated Pathways:
Metabolic Enzyme/Protease;PROTACApplications:
Cancer-programmed cell deathField of Research:
CancerAssay Protocol:
https://www.medchemexpress.com/protac-cyp1b1-degrader-2.htmlSmiles:
CC(C)([C@@H](C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O)NC(CCCCCCCOC4=CC=CC=C4C5=CSC(C6=CSC(NC7=CC=C(Cl)C=C7)=N6)=N5)=O)CMolecular Weight:
954.66References & Citations:
[1]Yao X, et al., Development of novel N-aryl-2,4-bithiazole-2-amine-based CYP1B1 degraders for reversing drug resistance. Eur J Med Chem. 2024 Jun 5;272:116488.Shipping Conditions:
Room temperatureClinical Information:
No Development ReportedCAS Number:
2836297-26-6