PROTAC CYP1B1 degrader-1

PROTAC CYP1B1 degrader-1

• CAS Number: 2411389-67-6
• UNSPSC Description: PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated agent resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1].
• Target Antigen: Cytochrome P450; PROTACs
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-cyp1b1-degrader-1.html
• Solubility: DMF : 10 mg/mL (ultrasonic)
• Smiles: COC1=CC=C(C2=C3OC(C4=CC=C(C=C4)C5=CN(N=N5)CCCCCCOC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=CC(C3=CC(OC)=C12)=O)OC
• Molecular Weight: 785.80
• References & Citations: [1]Li Zhou, et al. Design and synthesis of α-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation. Eur J Med Chem. 2020 Mar 1;189:112028.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported