CS-6253

• UNSPSC Description:

  CS-6253 is an agonist for ATP-binding cassette 1 (ABCA 1). CS-6253 improves the amyloid-β42/40 ratio, and affects lipoprotein metabolism in plasma. CS-6253 generates cholesterol-rich high-density lipoprotein (HDL) particles, and induces the release of microparticles[1][2].

• Target Antigen:

  Apolipoprotein

• Type:

  Peptides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cs-6253.html

• Purity:

  97.65

• Solubility:

  DMSO : 2 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (adjust pH to 10 with NaOH)

• Smiles:

  C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)C(C)C)=O)CCCNC(N)=O)=O)CO)=O)CCCCN)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCCCN)=O)CC(C)C)=O)CCCNC(=N)N)=O)C)=O)CC(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCCNC(N)=O)=O)CC(C)C)=O)C)=O)C)=O)CC(C)C)=O)C=1C=2C(NC1)=CC=CC2

• Molecular Weight:

  3055.48

• References & Citations:

  [1]Noveir SD, et al., Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys. Alzheimers Res Ther. 2022 Jun 24;14(1):87.|[2]Hafiane A, et al., ABCA1 Agonist Mimetic Peptide CS-6253 Induces Microparticles Release From Different Cell Types by ABCA1-Efflux-Dependent Mechanism. Can J Cardiol. 2019 Jun;35(6):770-781.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  Phase 1

• CAS Number:

  1627911-44-7