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[Pt (DACH) (OH) 2 (ox) ]

CAT: 0804-HY-W778423-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W778423-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
[Pt (DACH) (OH) 2 (ox) ] (Dihydroxy Oxaliplatin-Pt (IV) ) is a Oxaliplatin -based Pt (IV) scaffold. [Pt (DACH) (OH) 2 (ox) ] reacts with N-hydroxysuccinimide (NHS) ester of Pyropheophorbide-a (HY-128973) to yield phorbiplatin. Phorbiplatin is a highly potent Pt (IV) antitumor prodrug[1].
CAS Number
111321-67-6
Product Name Alternative
Dihydroxy Oxaliplatin-Pt (IV)
UNSPSC
12352300
Hazard Statement
H290-H301-H311-H315-H319-H331-H335-H340-H350
Target
Drug Intermediate
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
[OH-][Pt+4]12([NH2][C@@]3([H])[C@](CCCC3)([H])[NH2]1)([O-]C(C([O-]2)=O)=O)[OH-]
Molecular Formula
C8H16N2O6Pt
Molecular Weight
431.31
Precautions
P234-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P361+P364-P362+P364-P390-P403+P233-P405-P406-P501
References & Citations
[1]Wang Z, et al. Phorbiplatin, a highly potent Pt (IV) antitumor prodrug that can be controllably activated by red light. Chem, 2019, 5 (12) : 3151-3165.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dihydroxy oxaliplatin-Pt(IV)
CAS Number111321-67-6
PubChem CID15459431
IUPAC Nameoxalate;platinum(4+);trans-(1R,2R)-cyclohexane-1,2-diamine;dihydroxide
Molecular FormulaC8H16N2O6Pt
Molecular Weight431.31
Topological Polar Surface Area134
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count0
Heavy Atom Count17
Formal Charge0
Complexity123
SMILES
C1CC[C@H]([C@@H](C1)N)N.C(=O)(C(=O)[O-])[O-].[OH-].[OH-].[Pt+4]
InChI
InChI=1S/C6H14N2.C2H2O4.2H2O.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;;;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);2*1H2;/q;;;;+4/p-4/t5-,6-;;;;/m1..../s1
InChIKey
CRUOOYJLGQUXMM-NDSUJOINSA-J
Chemical Structure
2D Structure
2D structure of Dihydroxy oxaliplatin-Pt(IV)
CAS: 111321-67-6
CID: 15459431
Formula: C8H16N2O6Pt
MW: 431.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight431.31
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count0
Exact Mass431.065631
Monoisotopic Mass431.065631
Topological Polar Surface Area134 Ų
Heavy Atom Count17
Formal Charge0
Complexity123
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count5
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
GTR19260157[Pt (DACH) (OH) 2 (ox) ]
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