RORγ-IN-2

• Description:

  RORγ-IN-2 (Compound 22) is a RORγ inhibitor, with a Ki of 16.6 nM for hRORγ. RORγ-IN-2 can be used for the research of IL-17-dependent autoimmune diseases[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  ROR

• Related Pathways:

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CCS (C (C=N1) =CC=C1CNC (C2=CC3=C (C4 (O[C@H] (C3) C) CCN (CC4) [C@@H] (C5=CN=C (C (F) (F) F) N=C5) C) S2) =O) (=O) =O

• Molecular Formula:

  C28H32F3N5O4S2

• Molecular Weight:

  623.71

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Lugar CW, et al. Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt) . J Med Chem. 2021 May 13;64 (9) :5470-5484.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  RORγ

• CAS Number:

  2088333-58-6