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RORγ-IN-2

CAT: 0804-HY-W545294Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W545294Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RORγ-IN-2 (Compound 22) is a RORγ inhibitor, with a Ki of 16.6 nM for hRORγ. RORγ-IN-2 can be used for the research of IL-17-dependent autoimmune diseases[1].
CAS Number
[2088333-58-6]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
ROR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CCS(C(C=N1)=CC=C1CNC(C2=CC3=C(C4(O[C@H](C3)C)CCN(CC4)[C@@H](C5=CN=C(C(F)(F)F)N=C5)C)S2)=O)(=O)=O
Molecular Formula
C28H32F3N5O4S2
Molecular Weight
623.71
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Lugar CW, et al. Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt) . J Med Chem. 2021 May 13;64 (9) :5470-5484.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ

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