RORγ-IN-2

• Description :

  RORγ-IN-2 (Compound 22) is a RORγ inhibitor, with a Ki of 16.6 nM for hRORγ. RORγ-IN-2 can be used for the research of IL-17-dependent autoimmune diseases[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  ROR

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CCS(C(C=N1)=CC=C1CNC(C2=CC3=C(C4(O[C@H](C3)C)CCN(CC4)[C@@H](C5=CN=C(C(F)(F)F)N=C5)C)S2)=O)(=O)=O

• Molecular Formula :

  C28H32F3N5O4S2

• Molecular Weight :

  623.71

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Lugar CW, et al. Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt) . J Med Chem. 2021 May 13;64 (9) :5470-5484.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  RORγ

• CAS Number :

  [2088333-58-6]