GL-1196

• Description :

  GL-1196 is an inhibitor of PAK4. GL-1196 can suppress the proliferation and invasion of gastric cancer cells. GL-1196 inhibits PAK4-mediated signaling pathways. GL-1196 can hinder the proliferation of human gastric cancer cells through suppressing PAK4/c-Src/EGFR/CyclinD1 and CDK4/6. GL-1196 can reduce filamentous pseudopodia formation and induce filamentous pseudopodia formation and promote cell elongation in SGC7901 and BGC823 cells. GL-1196 can be studied in anti-cancer research[1][2].

• UNSPSC :

  12352005

• Target :

  PAK

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  O=S1(N=C(N(CC2=C(O)C=CC=C2)C3=CC=C(C=C3)Cl)C4=C1C=CC=C4)=O

• Molecular Formula :

  C20H15ClN2O3S

• Molecular Weight :

  398.86

• References & Citations :

  [1]Huang, G., et al., (2025) . P21-activated kinase 4: a potent oncogene, molecular mechanisms and opportunities for targeted therapy. Cancer cell international, 25 (1), 409.|[2]Zhang, J., et al., (2024) . Correction: Zhang et al. GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways. Int. J. Mol. Sci. 2016, 17, 470. International journal of molecular sciences, 25 (24), 13456.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [591242-70-5]