BWA-522 intermediate-3

• Description :

  BWA-522 intermediate-3 is a BWA-522 intermediate. BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7[1].

• UNSPSC :

  12352005

• Target :

  Drug Intermediate

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bwa-522-intermediate-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)(C1=CC=C(OC[C@H](O)CCl)C=C1)C2=CC=C(OCC3CCN(C(OC(C)(C)C)=O)CC3)C=C2

• Molecular Formula :

  C29H40ClNO5

• Molecular Weight :

  518.08

• References & Citations :

  [1]Zhang B, et al. Discovery of BWA-522, a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer. J Med Chem. 2023 Aug 24;66 (16) :11158-11186.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3032602-27-7]