SPI-05

• Description :

  SPI-05 (NSC 5067) is a non-competitive SUMO-specific proteases (SENP1/2) inhibitor (IC50=60 μM) . SPI-05 is promising for research of cancers, such as prostate cancer and hypoxia-driven solid tumors with SENP1 overexpression[1].

• Product Name Alternative :

  NSC 5067

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  E1/E2/E3 Enzyme

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  NC1=CC=C(C2=C1C=CC=C2)/N=N/C(C=C3)=CC([S](=O)(O)=O)=C3/C=C/C(C=CC(/N=N/C(C4=C5C=CC=C4)=CC=C5N)=C6)=C6[S](=O)(O)=O

• Molecular Formula :

  C34H26N6O6S2

• Molecular Weight :

  678.74

• Precautions :

  H315, H319

• References & Citations :

  [1]Madu IG, et al. Identification and characterization of a new chemotype of noncovalent SENP inhibitors. ACS Chem Biol. 2013 Jul 19;8 (7) :1435-41.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound2

• Clinical Information :

  No Development Reported

• CAS Number :

  [5463-64-9]