SPI-05

CAT: 0804-HY-W342380-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W342380-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SPI-05 (NSC 5067) is a non-competitive SUMO-specific proteases (SENP1/2) inhibitor (IC50=60 μM) . SPI-05 is promising for research of cancers, such as prostate cancer and hypoxia-driven solid tumors with SENP1 overexpression[1].
CAS Number
[5463-64-9]
Product Name Alternative
NSC 5067
UNSPSC
12352005
Hazard Statement
H315, H319
Target
E1/E2/E3 Enzyme
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC1=CC=C(C2=C1C=CC=C2)/N=N/C(C=C3)=CC([S](=O)(O)=O)=C3/C=C/C(C=CC(/N=N/C(C4=C5C=CC=C4)=CC=C5N)=C6)=C6[S](=O)(O)=O
Molecular Formula
C34H26N6O6S2
Molecular Weight
678.74
Precautions
H315, H319
References & Citations
[1]Madu IG, et al. Identification and characterization of a new chemotype of noncovalent SENP inhibitors. ACS Chem Biol. 2013 Jul 19;8 (7) :1435-41.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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