ESI-05

• Product Name Alternative:

  Mutagenic Impurity of Tenofovir Disoproxil; Tenofovir Impurity 2, (Z)-Mutagenic Impurity of Tenofovir Disoproxil

• UNSPSC Description:

  ESI-05 is a specific exchange proteins directly activated by cAMP 2 (EPAC2) inhibitor. ESI-05 inhibits cAMP-mediated EPAC2 GEF activity with an IC50 of 0.43 μM. ESI-05 can be used for the research of diabetes, insulin secretion and neurological disorders[1][2].

• Target Antigen:

  Acyltransferase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/esi-05.html

• Purity:

  99.94

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=C(C)C=C(C)C=C1C)(C2=CC=C(C)C=C2)=O

• Molecular Weight:

  274.38

• References & Citations:

  [1]Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8.|[2]Yan Zhuang, et al. Inhibition of EPAC2 Attenuates Intracerebral Hemorrhage-Induced Secondary Brain Injury via the p38/BIM/Caspase-3 Pathway. J Mol Neurosci. 2019 Mar;67(3):353-363.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  5184-64-5