GQC-05

• Description:

  GQC-05 (NSC338258), Ellipticine (HY-15753) derivative, is potent and selective c-Myc G-quadruplex (c-Myc G4) stabilizer with KD values of 0.1-1.43 μM. GQC-05 can reduce Myc expression and induce cancer cells apoptosis. GQC-05 can be used for the research of cancer, such as Burkitt lymphoma[1].

• Product Name Alternative:

  NSC 338258

• UNSPSC:

  12352005

• Target:

  Apoptosis; c-Myc; Drug Derivative

• Related Pathways:

  Apoptosis; Others

• Field of Research:

  Cancer

• Smiles:

  CN(C)CCOC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1

• Molecular Formula:

  C21H23N3O

• Molecular Weight:

  333.43

• References & Citations:

  [1]Brown RV, et al. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J Biol Chem. 2011 Nov 25;286 (47) :41018-27.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  501662-77-7