DC-05

• Description :

  DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively.

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  DNA Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/DC_05.html

• Purity :

  98.96

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC(CNCCC1=CNC2=C1C=CC=C2)CN(C3=CC=CC=C34)C5=C4C=CC=C5

• Molecular Formula :

  C25H25N3O

• Molecular Weight :

  383.49

• Precautions :

  H302

• References & Citations :

  [1]Chen S, et al. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57 (21) :9028-41.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  DNMT1

• CAS Number :

  [890643-16-0]