SPI-001

• UNSPSC Description:

  SPI-001 is a PPM1D-specific inhibitor (IC50=0.48 μM) with anticancer activity. SPI-001 inhibits PPM1D phosphatase activity and increases p53 phosphorylation in PPM1D-overexpressing human breast cancer cells. In addition, SPI-001 inhibits cell proliferation by inducing apoptosis[1].

• Target Antigen:

  Apoptosis; MDM-2/p53; Phosphatase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/spi-001.html

• Smiles:

  C[C@H]1C[C@@H](O[Si](CC)(CC)CC)[C@]2([H])[C@@]([C@@](C[C@@H](O)C[C@]3(CO)C)(C)[C@]3([H])[C@@H](O[Si](C)(C(C)(C)C)C)C2)([H])C1

• Molecular Weight:

  540.97

• References & Citations:

  [1]Yagi, et al. "A small molecule inhibitor of p53-inducible protein phosphatase PPM1D." Bioorganic & medicinal chemistry letters 22.1 (2012): 729-732.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  [1220996-46-2]