SPI-001

CAT: 0931-T89868-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T89868-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1220996-46-2
Target
Phosphatase|||Apoptosis|||MDM-2/p53
Related Pathways
Metabolism|||Apoptosis
Bioactivity
SPI-001 is a selective inhibitor of PPM1D (IC50=0.48 µM) that exhibits anticancer activity. The compound inhibits the phosphatase activity of PPM1D in human breast cancer cells overexpressing PPM1D and enhances the phosphorylation of p53. Additionally, SPI-001 suppresses cell proliferation by inducing apoptosis.
Smiles
C[C@@]12[C@]([C@@H](O[Si](C(C)(C)C)(C)C)C[C@]3([C@]1(C[C@@H](C)C[C@H]3O[Si](CC)(CC)CC)[H])[H])([C@@](CO)(C)C[C@H](O)C2)[H]
Molecular Formula
C30H60O4Si2
Molecular Weight
540.97
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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