SPI-001

• Target :

  Phosphatase|||Apoptosis|||MDM-2/p53

• Related Pathways :

  Metabolism|||Apoptosis

• Bioactivity :

  SPI-001 is a selective inhibitor of PPM1D (IC50=0.48 µM) that exhibits anticancer activity. The compound inhibits the phosphatase activity of PPM1D in human breast cancer cells overexpressing PPM1D and enhances the phosphorylation of p53. Additionally, SPI-001 suppresses cell proliferation by inducing apoptosis.

• Smiles :

  C[C@@]12[C@]([C@@H](O[Si](C(C)(C)C)(C)C)C[C@]3([C@]1(C[C@@H](C)C[C@H]3O[Si](CC)(CC)CC)[H])[H])([C@@](CO)(C)C[C@H](O)C2)[H]

• Molecular Formula :

  C30H60O4Si2

• Molecular Weight :

  540.97

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1220996-46-2