SPI-001

• Target:

  Phosphatase|||Apoptosis|||MDM-2/p53

• Related Pathways:

  Metabolism|||Apoptosis

• Bioactivity:

  SPI-001 is a selective inhibitor of PPM1D (IC50=0.48 µM) that exhibits anticancer activity. The compound inhibits the phosphatase activity of PPM1D in human breast cancer cells overexpressing PPM1D and enhances the phosphorylation of p53. Additionally, SPI-001 suppresses cell proliferation by inducing apoptosis.

• Smiles:

  C[C@@]12[C@] ([C@@H] (O[Si] (C (C) (C) C) (C) C) C[C@]3 ([C@]1 (C[C@@H] (C) C[C@H]3O[Si] (CC) (CC) CC) [H]) [H]) ([C@@] (CO) (C) C[C@H] (O) C2) [H]

• Molecular Formula:

  C30H60O4Si2

• Molecular Weight:

  540.97

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1220996-46-2