AGS-16C3F

• Description :

  AGS-16C3F is an antibody-drug conjugate (ADC) targeting ENPP3. AGS-16C3F is composed of ENPP3-targeting Anti-ENPP3/CD203c Antibody (HY-P990315) linked to Monomethyl auristatin F (HY-15579) via a linker. AGS-16C3F has anti-tumor activity and can be used in the study of metastatic renal cell carcinoma (mRCC) [1][2].

• Product Name Alternative :

  AGS-16M8F

• UNSPSC :

  12352203

• Target :

  Antibody-Drug Conjugates (ADCs) ; Phosphodiesterase (PDE)

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  99.81

• Smiles :

  [AGS-16C3F]

• References & Citations :

  [1]Kollmannsberger C, et al. A Randomized Phase II Study of AGS-16C3F Versus Axitinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma. Oncologist. 2021 Mar;26 (3) :182-e361.|[2]Zhang Y, et al. In vitro and in vivo efficacy of an anti-CD203c conjugated antibody (AGS-16C3F) in mouse models of advanced systemic mastocytosis. Blood Adv. 2019 Feb 26;3 (4) :633-643.

• Shipping Conditions :

  Dry Ice

• Storage Conditions :

  -80°C, protect from light

• Scientific Category :

  ADC Related

• Clinical Information :

  Phase 2

• Isoform :

  PDE3