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QX-314 (bromide) (Standard)

CAT: 0804-HY-101350RSize: 1 EachDry Ice: NoHazardous: No
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Description
QX-314 (bromide) (Standard) is the analytical standard of QX-314 (bromide). This product is intended for research and analytical applications. QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1].
CAS Number
24003-58-5
Target
Reference Standards; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease
Smiles
O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC.[Br-]
Molecular Formula
C16H27BrN2O
Molecular Weight
343.30
References & Citations
[1]Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114 (6) :1425-34.|[2]Binshtok AM, et al. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul;111 (1) :127-37.|[3]Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76 (3) :2120-4.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

QX-314 bromide

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CAS Number24003-58-5
PubChem CID9884487
IUPAC Name[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium bromide
Molecular FormulaC16H27BrN2O
Molecular Weight343.30
Topological Polar Surface Area29.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Heavy Atom Count20
Formal Charge0
Complexity268
SMILES
CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-]
InChI
InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
InChIKey
DLHMKHREUTXMCH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of QX-314 bromide
CAS: 24003-58-5
CID: 9884487
Formula: C16H27BrN2O
MW: 343.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight343.30
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count6
Exact Mass342.13068
Monoisotopic Mass342.13068
Topological Polar Surface Area29.1 Ų
Heavy Atom Count20
Formal Charge0
Complexity268
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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