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DRI-C25441

CAT: 0804-HY-154822-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-154822-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DRI-C25441 is a potent blocker of CD40 and CD40L interaction, with an IC50 of 0.36 μM. DRI-C25441 can inhibit the immune response induced by alloantigen. can inhibit CD40L induced activation of NF-κB signaling pathway. DRI-C25441 commonly is used in research on immune conditions [1][2].
CAS Number
2101765-83-5
UNSPSC
12352005
Target
NF-κB; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dri-c25441.html
Purity
99.53
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C2C=CC=CC2=C(NC(C3=CC=C(C4=CC=C(NC(C5=CC=C([N+]([O-])=O)C=C5)=O)C=C4)C=C3)=O)C=C1)O
Molecular Formula
C31H21N3O6
Molecular Weight
531.51
References & Citations
[1]Lu H, et, al. Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials. Signal Transduct Target Ther. 2020 Sep 23;5 (1) :213. |[2]Chen J, et al. Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction. J Med Chem. 2017 Nov 9;60 (21) :8906-8922.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNFRSF5/CD40

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