FOXO4-DRI

• Description:

  FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells[1].

• UNSPSC:

  12352209

• Target:

  Apoptosis; MDM-2/p53

• Type:

  Peptides

• Related Pathways:

  Apoptosis

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/foxo4-dri.html

• Purity:

  99.93

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (N[C@H] ([C@@H] (O) C) C (N[C@H] (CC (C) C) C (N[C@H] (CCCNC (N) =N) C (N[C@H] (CCCCN) C (N[C@H] (CCC (O) =O) C (N1[C@H] (CCC1) C (N[C@H] (C) C (N[C@H] (CO) C (N[C@H] (CCC (O) =O) C (N[C@H] ([C@H] (C) CC) C (N[C@H] (C) C (N[C@H] (CCC (N) =O) C (N[C@H] (CO) C (N[C@H] ([C@H] (C) CC) C (N[C@H] (CC (C) C) C (N[C@H] (CCC (O) =O) C (N[C@H] (C) C (N[C@H] (CC2=CC=C (C=C2) O) C (N[C@H] (CO) C (N[C@H] (CCC (N) =O) C (N[C@H] (CC (N) =O) C (NCC (N[C@H] (CC3=CNC4=CC=CC=C34) C (N[C@H] (C) C (N[C@H] (CC (N) =O) C (N[C@H] (CCCNC (N) =N) C (N[C@H] (CCCNC (N) =N) C (N[C@H] (CO) C (NCC (NCC (N[C@H] (CCCCN) C (N[C@H] (CCCNC (N) =N) C (N5[C@H] (CCC5) C (N6[C@H] (CCC6) C (N7[C@H] (CCC7) C (N[C@H] (CCCNC (N) =N) C (N[C@H] (CCCNC (N) =N) C (N[C@H] (CCCNC (N) =N) C (N[C@H] (CCC (N) =O) C (N[C@H] (CCCNC (N) =N) C (N[C@H] (CCCNC (N) =N) C (N[C@H] (CCCCN) C (N[C@H] (CCCCN) C (N[C@H] (CCCNC (N) =N) C (NCC (O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) [C@@H] (CC (C) C) N

• Molecular Formula:

  C228H388N86O64

• Molecular Weight:

  5358.06

• References & Citations:

  [1]Zhang C, et al. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (Albany NY) . 2020 Jan 20;12 (2) :1272-1284.|[2]Huang Y, et al. Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes. Front Bioeng Biotechnol. 2021 Apr 29;9:677576.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  2460055-10-9