FOXO4-DRI

CAT: 0804-HY-P4157-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P4157-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells[1].
CAS Number
[2460055-10-9]
UNSPSC
12352209
Target
Apoptosis; MDM-2/p53
Type
Peptides
Related Pathways
Apoptosis
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/foxo4-dri.html
Purity
99.93
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H]([C@@H](O)C)C(N[C@H](CC(C)C)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@H](CCC(O)=O)C(N1[C@H](CCC1)C(N[C@H](C)C(N[C@H](CO)C(N[C@H](CCC(O)=O)C(N[C@H]([C@H](C)CC)C(N[C@H](C)C(N[C@H](CCC(N)=O)C(N[C@H](CO)C(N[C@H]([C@H](C)CC)C(N[C@H](CC(C)C)C(N[C@H](CCC(O)=O)C(N[C@H](C)C(N[C@H](CC2=CC=C(C=C2)O)C(N[C@H](CO)C(N[C@H](CCC(N)=O)C(N[C@H](CC(N)=O)C(NCC(N[C@H](CC3=CNC4=CC=CC=C34)C(N[C@H](C)C(N[C@H](CC(N)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CO)C(NCC(NCC(N[C@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(N5[C@H](CCC5)C(N6[C@H](CCC6)C(N7[C@H](CCC7)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCC(N)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@H](CCCCN)C(N[C@H](CCCNC(N)=N)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CC(C)C)N
Molecular Formula
C228H388N86O64
Molecular Weight
5358.06
References & Citations
[1]Zhang C, et al. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (Albany NY) . 2020 Jan 20;12 (2) :1272-1284.|[2]Huang Y, et al. Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes. Front Bioeng Biotechnol. 2021 Apr 29;9:677576.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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