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F3288-0031

CAT: 0804-HY-179568Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179568Size:1 Each
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Description
F3288-0031 is a brain-penetrant norepinephrine transporter (NET) allosteric inhibitor with inhibitory rates of 73.5% at 20 μM. F3288-0031 binds within the inner vestibule of NET, stabilizing the inward-open state and has a preferential NET/SERT inhibition with pIC50 = 5.9. F3288-0031 shows no detectable off-target functional activity in vitro. F3288-0031 demonstrates robust antidepressant-like efficacy in vivo without confounding locomotor effects, F3288-0031 can be used for depressive disorder and related neuropsychiatric conditions[1].
CAS Number
926493-93-8
UNSPSC
12352005
Target
Monoamine Transporter
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
C/C=C/C1=CC(OC)=C(C=C1)OCC(CN2CCN(CC2)CC3=CC=CC=C3)O
Molecular Formula
C24H32N2O3
Molecular Weight
396.52
References & Citations
[1]Tang M, er al. Reversing the Warburg effect: Discovery of potent pyruvate dehydrogenase kinase inhibitors for inhibiting tumor growth. Bioorg Chem. 2025 Dec;167:109224.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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