CDD-1274

• Description:

  CDD-1274 is an ERα (Estrogen receptor α) variant inhibitor. CDD-1274 induces proteasomal degradation of ERα variants in breast cancer cell lines and causes Y537S ERα degradation. CDD-1274 potently blocks ligand-dependent and ligand-independent ER signaling in endocrine-resistant breast cancer cells. CDD-1274 can be used for the study of breast cancer[1].

• UNSPSC:

  12352005

• Target:

  Estrogen Receptor/ERR

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Smiles:

  O=C(NC)CCOCCC(N1CC(C2NCC3=CC(C4=CC(O)=CC=C4OC(F)(F)F)=CC=C3F)CCC2C1)=O

• Molecular Formula:

  C28H33F4N3O5

• Molecular Weight:

  567.57

• References & Citations:

  [1]Devakrishnan AK, et al. Discovery of a novel small molecule degrader of wild type and mutant estrogen receptors using DNA encoded libraries. NPJ Breast Cancer. 2025 Nov 12;11 (1) :125.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  ERα