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MK-0626

CAT: 0804-HY-179473Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179473Size:1 Each
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Description
MK-0626 is a selective, orally active DPP-4 inhibitor with an IC50 of 6.3 nM. MK-0626 increases endothelial nitric oxide synthetase expression. MK-0626 improves neovascularization, attenuates hepatic steatosis, attenuates pancreatic islet injury. MK-0626 can be used in the research of diabetes and non-alcoholic fatty liver disease[1][2][3].
CAS Number
[690257-74-0]
UNSPSC
12352005
Target
Dipeptidyl Peptidase; NO Synthase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease; Metabolic Disease
Smiles
O=C(N1CC(F)(CC1)F)[C@@H](N)[C@H](C2=CC=C(C3=CN4C(C=C3)=NC=N4)C=C2)C(N(C)C)=O
Molecular Formula
C22H24F2N6O2
Molecular Weight
442.46
References & Citations
[1]Shih CM, et al. MK-0626, a dipeptidyl peptidase-4 inhibitor, improves neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression. Curr Med Chem. 2014 Jun;21 (17) :2012-22. |[2]Ohyama T, et al. MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice. World J Gastroenterol. 2014 Nov 21;20 (43) :16227-35. |[3]Jin L, et al. Dipeptidyl peptidase IV inhibitor MK-0626 attenuates pancreatic islet injury in tacrolimus-induced diabetic rats. PLoS One. 2014 Jun 24;9 (6) :e100798.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-4

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