MK-3903

• Description:

  MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  AMPK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/MK-3903.html

• Purity:

  98.03

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  ClC1=CC2=C (NC (OC3=CC=C (C) C (C (O) =O) =C3) =N2) C=C1C (C=C4) =CC=C4C5=CC=CC=C5

• Molecular Formula:

  C27H19ClN2O3

• Molecular Weight:

  454.90

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Lan P, Romero FA, et al. Hit-to-Lead Optimization and Discovery of 5- ((5- ([1,1'-Biphenyl]-4-yl) -6-chloro-1H-benzo[d]imidazol-2-yl) oxy) -2-methylbenzoic Acid (MK-3903) : A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase. J Med Chem. 2017 Nov 9;60 (21) :9040-9052.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AMPK

• CAS Number:

  1219737-12-8