SJ-300

CAT: 0804-HY-179459Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179459Size:1 Each
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Description
SJ-300 is a potent and selective, orally active and brain-penetrat DKK3-LRP1 interaction inhibitor. SJ-300 restores Aβ clearance in AD models. SJ 300 binds to mLRPIV with a Kd of 7.9 μM, inhibits the DKK3 mLRPIV complex with an IC50 of 3.2 μM, and does not disrupt the binding of Aβ to LRP1. SJ 300 rescues cognitive function and ameliorates neuropathology (Aβ plaque reduction ≈ 73.3 %) in vivo. SJ 300 can be employed for research in Alzheimer’s disease[1].
CAS Number
[1210357-06-4]
UNSPSC
12352005
Target
Amyloid-β; LDLR; Wnt
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
FC1=CC=C(N2N=C(C)C(CNC3CCN(C4CC4)CC3)=C2C)C=C1
Molecular Formula
C20H27FN4
Molecular Weight
342.45
References & Citations
[1]Yang R, et al. DKK3-LRP1 complex and a chemical inhibitor regulate Aβ clearance in models of Alzheimer's disease. Sci Adv. 2025 Nov 7;11 (45) :eadz2099.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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