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SJ-C1044

CAT: 0931-T200357-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T200357-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2121503-76-0
Target
MEK|||ERK|||Tie-2|||Raf|||c-Fms|||Ras|||VEGFR
Related Pathways
MAPK|||GPCR/G Protein|||Angiogenesis|||Tyrosine Kinase/Adaptors
Bioactivity
SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 suppresses tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. Additionally, it shows inhibition of VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM respectively. The compound enhances the tumor immune microenvironment through inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is applicable for research in colorectal cancer.
Smiles
O=C(NC1=CC(=CC=C1F)NC2=NC=CC=C2C=3N=CN=C4N=CNC43)C=5C=C(C=C(C5)C(F)(F)F)C(F)(F)F
Molecular Formula
C25H14F7N7O
Molecular Weight
561.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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