SJ-C1044

CAT: 0804-HY-164529Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-164529Size:1 Each
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Description
SJ-C1044 is an orally available pan-RAF inhibitor with immunomodulatory and anti-tumor activities. SJ-C1044 inhibits wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 inhibits tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. In addition, SJ-C1044 also has a certain inhibitory effect on VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM, respectively. SJ-C1044 improves the tumor immune microenvironment by inhibiting angiogenesis and regulating macrophage function. SJ-C1044 can be used in the study of colorectal cancer[1].
CAS Number
[2121503-76-0]
UNSPSC
12352005
Target
C-Fms; ERK; MEK; Raf; Ras; Tie; VEGFR
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj-c1044.html
Smiles
FC(C(NC(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)=C2)=CC=C2NC3=NC=CC=C3C4=NC=NC5=C4N=CN5
Molecular Formula
C25H14F7N7O
Molecular Weight
561.41
References & Citations
[1]Sungpyo Hong, et al. "Targeting RAF isoforms and tumor microenvironments in RAS or BRAF mutant colorectal cancers with SJ-C1044 for anti-tumor activity." Current Issues in Molecular Biology 45.7 (2023) : 5865-5878.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; C-Raf; Tie2; VEGFR2/KDR/Flk-1

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