CIGB-300

• Description:

  CIGB-300 (P15-Tat) is an anti-casein kinase 2 (CK2) peptide that exhibits anticancer properties by interfering with the phosphorylation of protein kinase CK2. CIGB-300 induces apoptosis in multiple tumor cell lines and can be used in cancer research[1].

• Product Name Alternative:

  P15-Tat

• UNSPSC:

  12352209

• Target:

  Apoptosis; Casein Kinase

• Type:

  Peptides

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cigb-300.html

• Smiles:

  O=C(N[C@H](C(N[C@H](C(N1[C@](CCC1)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@](C(N[C@@H](CSSC[C@@H](C(N2)=O)NC(CCNC([C@H](CCC(N)=O)NC([C@H]3N(CCC3)C([C@H]4N(CCC4)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC(CN)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(O)=O)=O)([H])[C@H](O)C)=O)=O)CC(C)C)=O)CC5=CN=CN5)=O)CCCNC(N)=N)=O)=O)CO)=O)CCSC)[C@@H]2CC6=CNC7=CC=CC=C67

• Molecular Formula:

  C127H215N53O30S3

• Molecular Weight:

  3060.60

• References & Citations:

  [1]Perea S E, et al. CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo[J]. Molecular and cellular biochemistry, 2008, 316: 163-167.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  Phase 3

• CAS Number:

  [1072877-99-6]