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LE 300

CAT: 0804-HY-103428Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103428Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay[1][2].
CAS Number
274694-98-3
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/le-300.html
Purity
98.5
Solubility
DMSO : 29.04 mg/mL (ultrasonic; warming)
Smiles
CN1CCC2=C(NC3=C2C=CC=C3)CC4=CC=CC=C4CC1
Molecular Formula
C20H22N2
Molecular Weight
290.40
References & Citations
[1]Kassack MU, et al. Pharmacological characterization of the benz[d]indolo[2,3-g]azecine LE300, a novel type of a nanomolar dopamine receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2002 Dec;366 (6) :543-50. |[2]Rostom SA. Novel fused pyrrole heterocyclic ring systems as structure analogs of LE 300: Synthesis and pharmacological evaluation as serotonin 5-HT (2A), dopamine and histamine H (1) receptor ligands. Arch Pharm (Weinheim) . 2010 Feb;343 (2) :73-80.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; D1 Receptor; D5 Receptor; α-1 microglobulin

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