LE 300

• Description:

  LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay[1][2].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Dopamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/le-300.html

• Purity:

  98.5

• Solubility:

  DMSO : 29.04 mg/mL (ultrasonic; warming)

• Smiles:

  CN1CCC2=C(NC3=C2C=CC=C3)CC4=CC=CC=C4CC1

• Molecular Formula:

  C20H22N2

• Molecular Weight:

  290.40

• References & Citations:

  [1]Kassack MU, et al. Pharmacological characterization of the benz[d]indolo[2,3-g]azecine LE300, a novel type of a nanomolar dopamine receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2002 Dec;366 (6) :543-50. |[2]Rostom SA. Novel fused pyrrole heterocyclic ring systems as structure analogs of LE 300: Synthesis and pharmacological evaluation as serotonin 5-HT (2A), dopamine and histamine H (1) receptor ligands. Arch Pharm (Weinheim) . 2010 Feb;343 (2) :73-80.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT2 Receptor; D1 Receptor; D5 Receptor; α-1 microglobulin

• CAS Number:

  [274694-98-3]