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SJ-300

CAT: 0013-GTR19275335-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275335-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SJ-300 is a selective, orally active DKK3-LRP1 inhibitor capable of crossing the blood-brain barrier. It binds to mLRPIV with a Kd of 7.9 μM and inhibits the DKK3-mLRPIV complex with an IC50 of 3.2 μM, without affecting the interaction between Aβ and LRP1. In Alzheimer's disease models, SJ-300 restores Aβ clearance functionality, improves cognitive function, and reduces neuropathology by approximately 73.3% (Aβ plaque reduction) . SJ-300 is suitable for research related to Alzheimer's disease.
CAS Number
1210357-06-4
Smiles
FC1=CC=C (C=C1) N2N=C (C (=C2C) CNC3CCN (CC3) C4CC4) C
Molecular Formula
C20H27FN4
Molecular Weight
342.46
Storage Conditions
-20°C
Notes
For research use only.

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