CC-11

• Description :

  CC-11 is an orally active small molecule drug conjugate (SMDC) that links the PI3K/mTOR inhibitor with the extracellular heat shock protein 90 (EHSP90) targeting ligand through a cleavable linker. CC-11 exhibits strong HSP90 binding activity (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM) . CC-11 has anti-proliferative activity against colon cancer cells. CC-11 shows significant efficacy in the HCT-116 xenograft tumor model. CC-11 can be used for research on colon cancer[1].

• UNSPSC :

  12352005

• Target :

  Akt; HSP; mTOR; PI3K

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Field of Research :

  Cancer

• Smiles :

  CC(C1=CC(C(N2C3=CC=C(NC(CCC(NCC(OC4CCCN(C4)CCCN5C=C(N=N5)C6=CN=C7N6N=C(C=C7)C8=CC(NS(C9=CC=C(F)C=C9F)(=O)=O)=C(N=C8)OC)=O)=O)=O)C=C3CC2)=O)=C(C=C1O)O)C

• Molecular Formula :

  C52H54F2N12O10S

• Molecular Weight :

  1077.12

• References & Citations :

  [1]Wang Z, et al. Development of PI3K/mTOR-HSP90 ligand conjugates for improved colorectal cancer therapy. Eur J Med Chem. 2026 Jan 15;302 (Pt 2) :118286.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSP90; PI3Kα

• CAS Number :

  [3079942-94-9]