CC-90005

• Description :

  CC-90005 is a potent, selective and orally active inhibitor of protein kinase C-θ (PKC-θ), with an IC50 of 8 nM. CC-90005 shows selectivity for PKC-θ over PKC-δ (IC50=4440 nM) . CC-90005 can inhibit T cell activation by inhibiting IL-2 expression[1].

• CAS Number :

  [1799574-70-1]

• UNSPSC :

  12352005

• Target :

  PKC

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; TGF-beta/Smad

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/cc-90005.html

• Purity :

  99.67

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  N#CC1=CN=C(NCC2=CN=CN=C2OCC(F)(F)C)N=C1N[C@H]3CC(C)(C)[C@@H](O)CC3

• Molecular Formula :

  C21H27F2N7O2

• Molecular Weight :

  447.48

• References & Citations :

  [1]Papa P, et, al. Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005. J Med Chem. 2021 Aug 26;64 (16) :11886-11903.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  PKCθ