CC-647

• Description :

  CC-647 is a molecular glue modulator targeting Cereblon (CRBN) E3 ubiquitin ligase. CC-647 promotes the interaction between CRBN and ZBTB16 as well as its oncogenic fusion protein RARα-ZBTB16 (with a DC50 of 103 nM) . CC-647 is promising for research of ZBTB16-RARα-associated acute promyelocytic leukemia (APL) [1].

• UNSPSC :

  12352005

• Target :

  E1/E2/E3 Enzyme; Molecular Glues

• Related Pathways :

  Metabolic Enzyme/Protease; PROTAC

• Field of Research :

  Cancer

• Purity :

  99.58

• Solubility :

  DMSO : 35 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(OC4=CC=CC(C(C)(C)C)=C4)=CC=C2

• Molecular Formula :

  C23H22N2O5

• Molecular Weight :

  406.43

• References & Citations :

  [1]Matyskiela ME, et al. Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons. ACS Chem Biol. 2020 Dec 18;15 (12) :3149-3158.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1061605-35-3]