CC-90003

• Description :

  CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity.

• CAS Number :

  [1621999-82-3]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ERK

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/CC-90003.html

• Purity :

  99.71

• Solubility :

  DMSO : ≥ 125 mg/mL

• Smiles :

  C=CC(NC1=CC(C)=CC=C1NC2=NC(NC3=CC(OC)=NC=C3C)=NC=C2C(F)(F)F)=O

• Molecular Formula :

  C22H21F3N6O2

• Molecular Weight :

  458.44

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Monica M. Mita, et al. A phase Ia study of CC-90003, a selective extracellular signal-regulated kinase (ERK) inhibitor, in patients with relapsed or refractory BRAF or RAS-mutant tumors. Journal of Clinical Oncology 35, no. 15_suppl (May 20 2017) 2577-2577.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  ERK1; ERK2