CC-90003

• Description:

  CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ERK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/CC-90003.html

• Purity:

  99.71

• Solubility:

  DMSO : ≥ 125 mg/mL

• Smiles:

  C=CC(NC1=CC(C)=CC=C1NC2=NC(NC3=CC(OC)=NC=C3C)=NC=C2C(F)(F)F)=O

• Molecular Formula:

  C22H21F3N6O2

• Molecular Weight:

  458.44

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Monica M. Mita, et al. A phase Ia study of CC-90003, a selective extracellular signal-regulated kinase (ERK) inhibitor, in patients with relapsed or refractory BRAF or RAS-mutant tumors. Journal of Clinical Oncology 35, no. 15_suppl (May 20 2017) 2577-2577.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  ERK1; ERK2

• CAS Number:

  [1621999-82-3]