CC-11

CAT: 0013-GTR19273939-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19273939-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CC-11 is an orally bioavailable small molecule drug conjugate (SMDC) that links a PI3K/mTOR inhibitor to an extracellular heat shock protein 90 (EHSP90) targeting ligand via a cleavable linker. It exhibits strong binding activity to HSP90 (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM) . CC-11 shows antiproliferative effects against colon cancer cells and demonstrates significant efficacy in the HCT-116 xenograft model. It is applicable in colon cancer research.

CAS Number

3079942-94-9

Smiles

O=C (OC1CN (CCCN2N=NC (=C2) C3=CN=C4C=CC (=NN43) C=5C=NC (OC) =C (C5) NS (=O) (=O) C6=CC=C (F) C=C6F) CCC1) CNC (=O) CCC (=O) NC7=CC=C8C (=C7) CCN8C (=O) C=9C=C (C (O) =CC9O) C (C) C

Molecular Formula

C52H54F2N12O10S

Molecular Weight

1077.13

Storage Conditions

-20°C

Notes

For research use only.

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Alternative Products

Catalog	Name
HY-179457	CC-11
HY-P10534	Ccβ
309645-01	CCRL1, CT (CCBP2, CCR11, VSHK1, C-C Chemokine Receptor Type 11, C-C CKR-11, CC-CKR-11, CCR-11, CC Chemokine Receptor-like 1, CCRL1, CCX CKR)
309644-01	CCRL1, NT (CCBP2, CCR11, VSHK1, C-C Chemokine Receptor Type 11, C-C CKR-11, CC-CKR-11, CCR-11, CC Chemokine Receptor-like 1, CCRL1, CCX CKR)
C2100-20D	CCRL1, NT (CC-CKR-11, chemokine (C-C motif) receptor-like 1, CCBP2, CC chemokine receptor-like 1, C-C chemokine receptor type 11, CC-CKR-11, C-C CKR-11, CCR10, CCR11, CCR-11, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1) discontinued
BA4961-1	CC-90005
BA6460-100	CC-90001
BA3793-50	CC-671
B6114-5	CC-115
B6171-25	CC-223

CC-11

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