FTO-IN-14

• Target:

  Apoptosis

• Related Pathways:

  Apoptosis

• Bioactivity:

  FTO-IN-14 (Compound F97) is an inhibitor of the RNA demethylase Fat mass and obesity-associated protein (FTO), with an IC50 of 0.45 ?M. It modulates the expression of the ASB2, RARA, and MYC proteins. FTO-IN-14 demonstrates antiproliferative activity in AML cancer cells, with IC50 values of 0.7-5.5 ?M against MOLM13, NB4, HEL, OCI-AML3, MV4-11, and MONOMAC6, and induces apoptosis in NB4 cells. Additionally, FTO-IN-14 exhibits antitumor activity in a mouse NB4 xenograft model.

• Smiles:

  CC (NN=C1C) =C1C2=CC (C3CC3) =C (NC4=C (C (O) =O) SC=C4) C (C5CC5) =C2

• Molecular Formula:

  C22H23N3O2S

• Molecular Weight:

  393.502

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C