LSD1-IN-47

• Description:

  LSD1-IN-47 is a highly efficient PROTAC degrader targeting LSD1 (IC50 = 43 nM) . LSD1-IN-47 does not alter LSD1 protein levels and does not increase the histone marker H3K4me2. LSD1-IN-47 can be used for the study of colon carcinoma[1].

• UNSPSC:

  12352005

• Target:

  Histone Demethylase; PROTACs

• Related Pathways:

  Epigenetics; PROTAC

• Field of Research:

  Cancer

• Smiles:

  CC1=C (SC=N1) C2=CC=C (C=C2) CNC ([C@@H]3C[C@H] (CN3C ([C@H] (C (C) (C) C) NC (CCCCCCCCCCCNC (C4=CC=C ([C@H]5[C@H] (N) C5) C=C4) =O) =O) =O) O) =O

• Molecular Formula:

  C44H62N6O5S

• Molecular Weight:

  787.07

• References & Citations:

  [1]Coulson ME, et al. Synthetic and structure-activity studies of SP2577 and TCP towards LSD1 targeting PROTACs. RSC Med Chem. 2025 Aug 5;16 (10) :4952-4959.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported