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LSD1-IN-47

CAT: 0804-HY-179229Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179229Size:1 Each
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Description
LSD1-IN-47 is a highly efficient PROTAC degrader targeting LSD1 (IC50 = 43 nM) . LSD1-IN-47 does not alter LSD1 protein levels and does not increase the histone marker H3K4me2. LSD1-IN-47 can be used for the study of colon carcinoma[1].
UNSPSC
12352005
Target
Histone Demethylase; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCCCCCNC(C4=CC=C([C@H]5[C@H](N)C5)C=C4)=O)=O)=O)O)=O
Molecular Formula
C44H62N6O5S
Molecular Weight
787.07
References & Citations
[1]Coulson ME, et al. Synthetic and structure-activity studies of SP2577 and TCP towards LSD1 targeting PROTACs. RSC Med Chem. 2025 Aug 5;16 (10) :4952-4959.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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