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COX-2-IN-60

CAT: 0804-HY-179142Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179142Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COX-2-IN-60 is a potent, orally active, and selective  COX-2  inhibitor with an IC50 of 0.06 μM. COX-2-IN-60 exhibits ~100-fold selectivity over  COX-1 (IC50 = 5.93). COX-2-IN-60 reduces oxidative stress and neuroinflammatory cytokines, and effectively counteracts epileptogenesis. COX-2-IN-60 exhibits significant anticonvulsant effects and protects against hippocampal injury by suppressing oxidative stress (reducing MDA  and NO), pro-inflammatory signaling (reducing TNF-α and IL-6), and glial activationin in the Pilocarpine -induced seizure mouse model. COX-2-IN-60 can be used for the research on  neuroinflammatory and  epilepsy[1].
CAS Number
3073624-74-2
UNSPSC
12352005
Target
COX; Interleukin Related; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(O)COC1=CC=C(Br)C=C1/C=N/NC(CC2=CC=CC=C2)=O
Molecular Formula
C17H15BrN2O4
Molecular Weight
391.22
References & Citations
[1]Elgohary MK, et al. Discovery and characterization of phenoxyacetic acid derivatives as potential antiepileptic agents. RSC Adv. 2025;15 (46) :39161-39179. Published 2025 Oct 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2

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