HDAC8-IN-14

• Description:

  HDAC8-IN-14, a curcuminoid derivative, is a selective HDAC8 inhibitor with a Ki of 9 nM. HDAC8-IN-14 induces the production of reactive oxygen species (ROS), disrupts mitochondrial membrane potential, and promotes apoptosis. HDAC8-IN-14 can significantly promote the accumulation of cells in the sub-G0/G1 phase, consistent with apoptotic or necrotic cell death. HDAC8-IN-14 induces upregulation of cytochrome c, cleaved caspase-3, and the pro-apoptotic protein Bak while leaving the anti-apoptotic Bcl-2 levels unaltered. HDAC8-IN-14 can be used for the study of leukemia[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Bcl-2 Family; Biochemical Assay Reagents; Caspase; HDAC; Necroptosis; Reactive Oxygen Species (ROS)

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  O=C1/C (CNC/C1=C\C2=CN (C3=CC=CC=C3) N=C2C4=CC=C (Cl) C=C4) =C/C5=CN (C6=CC=CC=C6) N=C5C7=CC=C (Cl) C=C7

• Molecular Formula:

  C37H27Cl2N5O

• Molecular Weight:

  628.55

• References & Citations:

  [1]Sudarshan V, et al. Assessing the anti-leukemic efficacy of a curcuminoid in cellular and animal models. Eur J Med Chem. 2025 Dec 15;300:118177.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 3; HDAC8