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MAO-B-IN-49

CAT: 0804-HY-178352Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178352Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAO-B-IN-49 is a selective and reversible MAO-B inhibitor (IC50 of 1 nM for human MAO-B). MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A (IC50 = 633.9). MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP (HY-W114750) -induced mouse models of Parkinson’s disease (PD). MAO-B-IN-49 can be used for the study of PD[1].
CAS Number
3098883-91-8
UNSPSC
12352005
Target
Monoamine Oxidase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
C[C@H](N1CCOC2=C(C1)C=CC(OCC3=CC(F)=C(C=C3)F)=C2)C(N)=O
Molecular Formula
C19H20F2N2O3
Molecular Weight
362.37
References & Citations
[1]Zhu M, et al. Design, synthesis, and biological evaluation of highly potent and selective hMAO-B inhibitors featuring a tetrahydrobenzo[f][1,4]oxazepine core. Eur J Med Chem. 2025 Dec 5;299:118080.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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