Debio 1453

CAT: 0804-HY-178347Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178347Size:1 Each
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Description
Debio 1453 is a bactericidal FabI inhibitor potent against N. gonorrhoeae (IC50 = 0.6 nM), including drug-resistant strains. Debio 1453 demonstrates a low propensity for resistance selection and is effective in eradicating both planktonic and intracellular bacteria through a mechanism of concurrently inhibiting FabI and engaging the non-mutable NADH cofactor. Debio 1453 clears antibiotic-resistant N. gonorrhoeae infection in a murine vaginal model. Debio 1453 can be used for gonorrhoea research[1].
CAS Number
[2422053-29-8]
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
CC1=C(OC2=C1C=CC=C2)CN(C(/C=C/C3=CN=C4NC([C@H]([C@H](NC4=C3)C)O)=O)=O)C
Molecular Formula
C23H24N4O4
Molecular Weight
420.46
References & Citations
[1]Gerusz V, et al. The bactericidal FabI inhibitor Debio 1453 clears antibiotic-resistant Neisseria gonorrhoeae infection in vivo. Nat Commun. 2025 Sep 18;16 (1) :8309.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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