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Debio 0617B

CAT: 0804-HY-108417Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-108417Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs) . Debio 0617B has documented efficacy in STAT3-driven solid tumors[1].
CAS Number
[1332329-27-7]
UNSPSC
12352005
Target
Bcr-Abl; JAK; STAT
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/debio-0617b.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC=CC(C(F)(F)F)=C1)NC2=CC=C(Cl)C(N3CCC4=NC(NC5=CC=C(C(NC)=O)C=C5)=NC=C4C3)=C2
Molecular Formula
C28H23ClF3N7O2
Molecular Weight
581.98
References & Citations
+
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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