Debio 0617B

• Description :

  Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs) . Debio 0617B has documented efficacy in STAT3-driven solid tumors[1].

• CAS Number :

  [1332329-27-7]

• UNSPSC :

  12352005

• Target :

  Bcr-Abl; JAK; STAT

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/debio-0617b.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=NC=CC(C(F)(F)F)=C1)NC2=CC=C(Cl)C(N3CCC4=NC(NC5=CC=C(C(NC)=O)C=C5)=NC=C4C3)=C2

• Molecular Formula :

  C28H23ClF3N7O2

• Molecular Weight :

  581.98

• References & Citations :

  +

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported