Debio 0617B

• Target :

  Others|||JAK|||STAT|||Bcr-Abl

• Related Pathways :

  Others|||Chromatin/Epigenetic|||Stem Cells|||Cytoskeletal Signaling|||Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors

• Bioactivity :

  Debio 0617B is a multi-kinase inhibitor that reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. debio 0617B targets key kinases upstream of STAT3/STAT5 signalling, such as JAK, ABL, SRC and class III/V receptor tyrosine kinases. debio 0617B can be used to study STAT3 driven solid tumours.

• Smiles :

  ClC=1C(N2CC=3C(CC2)=NC(NC4=CC=C(C(NC)=O)C=C4)=NC3)=CC(NC(=O)C5=CC(C(F)(F)F)=CC=N5)=CC1

• Molecular Formula :

  C28H23ClF3N7O2

• Molecular Weight :

  581.98

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1332329-27-7