Debio 0617B

• Target:

  Others|||JAK|||STAT|||Bcr-Abl

• Related Pathways:

  Others|||Chromatin/Epigenetic|||Stem Cells|||Cytoskeletal Signaling|||Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors

• Bioactivity:

  Debio 0617B is a multi-kinase inhibitor that reduces maintenance and self-renewal of primary human AML CD34+ stem/progenitor cells. debio 0617B targets key kinases upstream of STAT3/STAT5 signalling, such as JAK, ABL, SRC and class III/V receptor tyrosine kinases. debio 0617B can be used to study STAT3 driven solid tumours.

• Smiles:

  ClC=1C (N2CC=3C (CC2) =NC (NC4=CC=C (C (NC) =O) C=C4) =NC3) =CC (NC (=O) C5=CC (C (F) (F) F) =CC=N5) =CC1

• Molecular Formula:

  C28H23ClF3N7O2

• Molecular Weight:

  581.98

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1332329-27-7