EC-1456

CAT: 0804-HY-P1653Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-P1653Size:Inquire
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CAS Number
[1602487-16-0]
UNSPSC Description
EC-1456 is a folate-tubulysin conjugate with significant anti-proliferative activity against FR-positive tumors, including models which were anticancer drug resistant. EC-1456 can be utilized in cancer research[1].
Target Antigen
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ec-1456.html
Smiles
O=C([C@@H]1N(CCCC1)C)N[C@@H]([C@@H](C)CC)C(N(COC(CCC)=O)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(NNC(OCCSSC[C@H](C(O)=O)NC([C@H](CCC(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)NC([C@@H](CCC(O)=O)NC([C@H](CCC(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)NC([C@@H](CCC(O)=O)NC([C@H](CCC(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)NC(CC[C@H](C(O)=O)NC(C3=CC=C(C=C3)NCC(N=C45)=CNC4=NC(N)=NC5=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CC=C(C=C6)O)=O)=CS2)OC(C)=O)=O
Molecular Weight
2625.81
References & Citations
[1]Reddy JA, et al. Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic. Sci Rep. 2018 Jun 12;8(1):8943.
Shipping Conditions
Room temperature
Clinical Information
Phase 1

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