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MDOLL-0286

CAT: 0804-HY-178208-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-178208-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDOLL-0286 is a selective Poly (ADP-ribose) Glycohydrolase (PARG) (ARH3) inhibitor with an IC50 of 2.3μM. MDOLL-0286 can inhibit ARH3’s poly-ADP-ribose hydrolytic activity on cellular substrates. MDOLL-0286 can inhibit DNA damage response. MDOLL-0286 can be used for the research of cancer [1].
UNSPSC
12352005
Target
Poly (ADP-ribose) Glycohydrolase (PARG)
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N=C(N/N=C(C2=CC=C(N(C)C)C=C2)\C)NC(C)=C1C
Molecular Formula
C16H21N5O
Molecular Weight
299.37
References & Citations
[1]Parviainen TAO, et al. Discovery and Structural Optimization of 2-Hydrazinopyrimidin-4-one Analogs Inhibiting Human ADP-Ribosylhydrolase ARH3. ACS Chem Biol. 2025 Sep 15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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