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PTC-028

CAT: 0804-HY-103696-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103696-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis[1].
CAS Number
[1782970-28-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; BMI1
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ptc-028.html
Purity
98.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(C1=CC=C(NC2=NC(N3C4=CC(F)=C(F)C=C4N=C3C)=CN=C2)C=C1)(F)F
Molecular Formula
C19H12F5N5
Molecular Weight
405.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Dey A, et al. Evaluating the Mechanism and Therapeutic Potential of PTC-028, a Novel Inhibitor of BMI-1 Function in Ovarian Cancer. Mol Cancer Ther. 2018 Jan;17 (1) :39-49.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
M12682-01PTC-028
A16812-2PTC-028 2mg
A16812-25PTC-028 25mg
A16812-500PTC-028 500mg
A16812-5PTC-028 5mg
A16812-100PTC-028 100mg
A16812-1PTC-028 1mg
A16812-10PTC-028 10mg
A16812-50PTC-028 50mg
A16812-10mM-DPTC-028 10mM * 1mL in DMSO

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