BI-0282

• UNSPSC Description:

  BI-0282 (Compound 1) is a potent MDM2-p53 interaction inhibitor[1].

• Target Antigen:

  MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bi-0282.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=C(C=CC=C1[C@@H]([C@@H]2N3C4=C5C=CC(C(O)=O)=CC5=N3)[C@]6(C(NC7=C6C=CC(Cl)=C7)=O)N([C@H]2CO4)CC8CC8)Cl

• Molecular Weight:

  593.43

• References & Citations:

  [1]Ramharter J, et al. Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis–Beirut Reaction. Organic Process Research & Development, 2022.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1883383-48-9