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BIIB-028

CAT: 0804-HY-12933Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12933Size:1 Each
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Description
BIIB-028 is an orally active inhibitor for heat shock protein 90 (Hsp90) . BIIB-028 targets the ATP-binding site of Hsp90, disrupts the function of Hsp90, leads to the degradation of client proteins, that are crucial for cancer cell survival and proliferation[1][2].
CAS Number
911398-13-5
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/biib-028.html
Smiles
CC(C(OC)=C(C)C=N1)=C1CN2C3=NC(N)=NC(Cl)=C3C(C#CCCOP(O)(O)=O)=C2
Molecular Formula
C19H21ClN5O5P
Molecular Weight
465.83
References & Citations
[1]Soga S, et al., Hsp90 inhibitors as anti-cancer agents, from basic discoveries to clinical development. Curr Pharm Des. 2013;19 (3) :366-76.|[2]Rahimi M N. Investigating cyclic peptide inhibitors of heat shock protein 90 (Hsp90) : from design and synthesis to cellular drug delivery[D]. UNSW Sydney, 2020.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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